Quantitative EEG Reveals Cognitive and Motor Restoration After Biophoton Treatment in Chronic Stroke
Author(s):
James Z Liu1,2*, Mariola A Smotrys1,2, Seth D Robinson2, Hui X Yu2, Sherry X Liu2, Devin R Liu2 and Helen Y Gu1,2
Background: Chronic stroke is a leading cause of long-term neurological disability, with limited therapeutic options for restoring brain function beyond
the acute recovery window. Recent advances in biophoton therapy suggest a novel approach to promote neuroplasticity through non-invasive, energybased
mechanisms. This study aimed to evaluate the neurophysiological effects of strong biophoton generator therapy in patients with chronic stroke using
quantitative EEG (qEEG) and behavioral metrics.Methods: Five patients aged 63-77 years with confirmed chronic stroke received nightly exposure to four strong biophoton generators for 4 consecutive
weeks. EEG recordings were acquired at baseline, Week 2, and Week 4 using the BrainView system. Primary outcomes included posterior alpha frequency,
theta/beta ratio, frontal alpha asymmetry, and event-related potentials (P2, P3, P3b). Secondary outcomes included reaction time, error rate, and patientreported
symptoms. EEG data were analyzed longitudinally to assess progressive neurofunctional change.Results: Across patients, biophoton therapy was associated with increased posterior alpha frequency (mean +0.3–0.5 Hz), reduced theta/beta ratios (mean
–0.05 to –0.1), and shortened P3 and P3b latencies (mean –16 to –20 ms), indicating enhanced cortical processing and attentional regulation. Behavioral
improvements included reduced reaction time variability, fewer missed responses, and self-reported improvements in balance and strength. Placebo-treated
control data showed no significant EEG or behavioral change.Conclusion: Biophoton therapy may stimulate measurable recovery in chronic stroke patients, as reflected by improved EEG biomarkers and cognitivebehavioral
outcomes. These findings highlight the potential of bioenergetic interventions to activate latent neural plasticity, offering a promising nonpharmacological
option for post-stroke rehabilitation.
