The Effect of Sputnik V COVID-19 Vaccine on the Body Weight of Mice
Author(s):
Emhemmed Ali Elgallal1, Inass A Sadawe2, Abdelmonam Hadi Elghobassa1, Abdulathim A A Alshoushan1, Salah M Bensaber3, Jamal Ali M.
Elbakay3, Nisreen H Meiqal3, Massaud Salem Maamar4, Anton Hermann5
and Abdul M Gbaj3*
Background and Aim: Efforts are being made to discover the proper vaccine against COVID-19. After discovering such a vaccine, its acceptance is an essential subject for disease control. The present study aims to determine the effect of weight gain of Sputnik V COVID-19 vaccine on mice compared to control group.
Materials and Methods: This experimental study was performed on mice weighing on average of 20 g, selected by random allocation method. The mice were divided into two groups of 12 (one control group and one case group), receiving 0.5 ml Sputnik V COVID-19 vaccine.
Results: The weight gain of mice among the two groups after 15 days was significantly higher compared to the control group (p<0.05).
Conclusion: The use of Sputnik V COVID-19 vaccine has a significant effect on body weight compared to the control group and could be related to the human adenovirus. Evaluating body composition or histopathological assessments are suggested.
