Complex Treatment for Analaplastic G3 Meningioma- Clinical Case with Literature Review
Author(s):
Lena Marinova*, Vaska Vassileva, Viktor Petrov, Iliya Gabrovski and Galin Vulchev
Anaplastic meningiomas are rare aggressive brain neoplasms that are followed by recurrences, despite a gross total surgery.
We present a 45-year-old woman with an anaplastic meningioma recurrence two years after surgery, which is not followed by postoperative raditherapy. Through this clinical case, we emphasize the required diagnostics and complex treatment in analaplastic meningiomas as well as the current optimization options of imposing surgical intervention, radiotherapy and drug treatment.
?he standard care is maximum safe resection followed by adjuvant raditherapy (RT) for grade 3 meningiomas. Radiosurgery (RS) is an effective therapeutic alternative for intracranial and spinal meningiomas up to 3.5 cm. Hypofractionated radiosurgery (HFRS) is administered postoperatively in analaplastic meningiomas with a diameter of more than 3.5 cm. After re-operation of recurrences and after 6 months of the previous radiotherapy, it is possible to conduct HFRS re-irradiation, followed by targeted therapy.
