Author(s): Akira Yagi
The global coronavirus disease (COVID)-19 pandemic has become a huge threat to humans. Intensive research on the pandemic mechanisms used by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is urgently needed-notably to identify potential drug targets. Clinical studies of patients with COVID-19 have shown that gastrointestinal disorders appear to precede or follow the respiratory symptoms. Here we review exploratory approaches for the use of aloe for COVID treatment, gastrointestinal disorders in patients with COVID-19, suggest hypothetical mechanisms leading to gut symptoms, and discuss the potential consequences of gastrointestinal disorders on the outcome of the disease. Lastly, we discuss the role of the gut microbiota during respiratory viral infections and suggest that targeting food supplement and gut dysbiosis by use of Aloe vera may help to control immunomodulatory effect to the pathogenesis of COVID-19
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